Clinical Trial

Early Aggressive Strategy for Treatment of Lipid-Lowering in Acute Ischemic Stroke Delivered With Endovascular Therapy for Large Artery Occlusion

Study acronym: EAST-LDL
Recruiting Phase 3
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Summary
A prospective, multicenter, open-label, randomized controlled study to assess the effects of early intensive lipid-lowering initiated before endovascular treatment setting on (i) functional outcome in patients with acute ischemic stroke between preoperative intensive lipid-lowering therapy with PCSK9 inhibitor (PCSK9i) and guideline-recommended standard of care (SoC)(ii) safety in these patients.
Protocol Amendment History 1 amendment
This ClinicalTrials.gov record has been amended once since 2025-06-02.
Status change: Not Yet Recruiting → Recruiting 2026-01-18
Trial Details
NCT Number NCT07002476
Lead Sponsor Shanghai East Hospital
Conditions Stroke
Enrollment 652 participants
Start Date 2025-06-19
Primary Completion 2028-06-01 (estimated)
Study Completion 2029-01-01 (estimated)
Updated on ClinicalTrials.gov 2026-01-21