Telehealth Exercise Program Evaluating Fatigue and Physical Function in Rural Cancer Survivors

This study investigates the efficacy of a telehealth exercise program designed specifically for rural cancer survivors with cancer-related fatigue (CRF). Small dried blood samples and measures of physical function will be collected throughout the program. The main questions it aims to answer are: * Does the exercise program improve CRF in rural cancer survivors? * How do CRF, metabolism, and physical function change during the exercise program? Researchers will compare the program to a wait-list control group. This group will complete all study measures without without changing current physical activity before receiving the full exercise program. Participants will: * Complete a virtual physical assessment before and after the program. * Complete brief virtual assessments and collect dried blood samples (at home and mailed in) every two weeks during the program. * Receive a personalized exercise program including virtual sessions and remote exercise programming with a cancer exercise specialist (after a 12-week wait period in the wait-list control group). * Optional: Willing participants will visit a study site for a laboratory-based exercise assessment before and after the program.

NCT Number	NCT07001241
Lead Sponsor	University of Colorado, Denver Collaborators: National Cancer Institute (NCI)
Conditions	Cancer-related Fatigue, Breast Cancer, Prostate Cancer
Enrollment	134 participants
Start Date	2025-10-08
Primary Completion	2028-08 (estimated)
Study Completion	2030-12 (estimated)
Updated on ClinicalTrials.gov	2026-02-05