Clinical Trial

Intraoperative Nebulization of Lidocaine and Postoperative Pulmonary Complications

Completed Phase 3
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Summary
There is high incidence of postoperative pulmonary complications (PPCs) in patients undergoing major abdominal surgeries.PPCs significantly prolongs the hospital stay of patients, increases their economic burden, and raises the mortality rates within 30 days and 1 year after surgery. The inflammatory response during the perioperative period plays an important role in the occurrence and development of PPCs. The anti-inflammatory effect of lidocaine has a potential lung protection mechanism. The purpose of this study is to explore the effect of nebulization of lidocaine on the incidence of PPCs. The investigators hypothesized that intraoperative nebulization of lidocaine could reduce the incidence of PPCs.
Protocol Amendment History 3 amendments
This ClinicalTrials.gov record has been amended 3 times since 2025-05-31; most recent amendment 2026-03-07.
Status change: Recruiting → Completed 2026-02-22
Status change: Not Yet Recruiting → Recruiting 2025-12-20
Trial Details
NCT Number NCT07000760
Lead Sponsor Jun Zhang
Conditions Postoperative Pulmonary Complications (PPCs)
Enrollment 270 participants
Start Date 2025-06-06
Primary Completion 2026-01-23 (estimated)
Study Completion 2026-01-30 (estimated)
Updated on ClinicalTrials.gov 2026-03-10