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Transcranial Doppler as a Predictor of Postoperative Cognitive Dysfunction Following Cardiopulmonary Bypass

StatusRecruiting
PhaseNot specified
Started
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Record status
This record was last updated February 17, 2026 (before its estimated March 31, 2026 completion). Its status may not reflect the trial's current state.

Record History

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  1. Primary endpoints: 7 to 3v2 Show 4 more changesShow less
    • Start date: Apr 1, 2025 to Apr 17, 2025
    • Interventions: Group Non-pulsatile perfusion (Procedure) to Transcranial Doppler measurement of the middle cerebral artery (Procedure)
    • Secondary endpoints revised (4)
    • Study arms: 1 to 2
  2. Study First Submitted
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
Neurological dysfunction either transient or permanent is a major cause of morbidity and mortality after cardiopulmonary bypass, and cognitive dysfunction is more frequent in cardiac surgery than in non-cardiac procedures. Variations in cerebral blood flow and oxygen extraction are considered key contributing factors. Although pulsatile flow during bypass has shown benefits for renal function and recovery, its effects on postoperative neurological dysfunction and delirium remain unclear due to limited research. This study aims to evaluate the impact of pulsatile versus non-pulsatile cardiopulmonary bypass flow on POCD in adult CABG patients by measuring middle cerebral artery (MCA) flow using transcranial Doppler.
Trial Details
NCT Number NCT07000461
Lead Sponsor Bakirkoy Dr. Sadi Konuk Research and Training Hospital
Conditions
(from sponsor)		 Postoperative Cognitive Dysfunction, Delirium, Postoperative
Related terms Delirium, Emergence Delirium, Postoperative Cognitive Complications
Enrollment 106 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov