Clinical Trial

Preoperative Pregabalin vs Gabapentin in Elderly Undergoing Surgry,Controlled Trial

Not Yet Recruiting

Record status

This record was last updated July 4, 2025 (before its estimated December 15, 2025 completion). Its status may not reflect the trial's current state.

Summary

Several studies have evaluated the efficacy of pregabalin in reducing preoperative anxiety, with inconsistent results. Similarly, inconclusive results have been reported regarding gabapentin and its effects in reducing preoperative anxiety. A previous study reported that a single dose of gabapentin or pregabalin administered 60 minutes before surgery in adults under general anesthesia was effective in reducing acute preoperative anxiety and elevated levels of sedation before and after surgery, with pregabalin having better anxiolytic and sedative effects than gabapentin. However, no previous studies have compared the efficacy of preoperative pregabalin or gabapentin as premedication to reduce intraoperative anxiety and induce sedation in geriatric patients undergoing major surgery with regional anesthesia

Protocol Amendment History 2 amendments

This ClinicalTrials.gov record has been amended 2 times since 2025-05-23; most recent amendment 2025-07-02.

Trial Details

NCT Number	NCT07000201
Lead Sponsor	Cairo University
Conditions	Anxiety, Anxiety Disorder (Panic Disorder or GAD)
Enrollment	84 participants
Start Date	2025-09-15
Primary Completion	2025-12-15 (estimated)
Study Completion	2025-12-30 (estimated)
Updated on ClinicalTrials.gov	2025-07-04