Clinical Trial

Dexamethasone Palmitate for PONV After Open Surgery

Recruiting
View on ClinicalTrials.gov →
Summary
Dexamethasone is almost one of the most commonly used drugs for postoperative nausea and vomiting (PONV) prevention. However, PONV is still a complex problem to be solved; for example, even with preoperative dexamethasone administration, there are still some patients still experience PONV within 24 hours postoperatively. Compared to dexamethasone, dexamethasone palmitate has a long-lasting anti-inflammatory effect, 2-5 times that of traditional water-soluble dexamethasone, with fewer adverse effects. This trial aims to assess the effect and safety of preoperative dexamethasone palmitate on PONV after open surgery.
Protocol Amendment History 1 amendment
This ClinicalTrials.gov record has been amended once since 2025-05-21.
Status change: Not Yet Recruiting → Recruiting 2025-09-21
Trial Details
NCT Number NCT06997419
Lead Sponsor Beijing Tiantan Hospital
Conditions Postoperative Nausea and Vomiting, Dexamethasone Palmitate, Open Surgery
Enrollment 500 participants
Start Date 2025-07-01
Primary Completion 2026-11-30 (estimated)
Study Completion 2026-12-31 (estimated)
Updated on ClinicalTrials.gov 2025-09-23