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CHinese ischEmic Stroke Beyond 4.5 Hours With TeNecteplase Under Optimized Non-Contrast CT Selection

Study acronym: CHESTNUT
StatusRecruiting
PhasePhase 3
Started
View on ClinicalTrials.gov ↗

Record History

See every version on ClinicalTrials.gov ↗

  1. Trial status: Not Yet Recruiting to Recruiting
    • Study sites: 1 to 2
    • Start date changed from estimate of Nov 2025 to Nov 3, 2025
    v5
  2. Start date: Jun 2025 to Nov 2025
    • Primary completion date: Nov 2027 to Mar 2028
    • Study completion date: Nov 2027 to Jun 2028
    v4
  3. Eligibility criteria expanded, about 14 words
    • Study description shortened, about 1 word
    • Study title shortened, about 2 words
    v3
  4. Primary endpoint revised
    • Secondary endpoints revised (11)
    • Study description expanded, about 3 words
    v2
  5. Study First Submitted
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
Huashan Hospital
96 trials monitored
See 4 trials at risk
Stroke
3,531 trials monitored
See 153 trials at risk
The CHESTNUT trial is a multicenter, open-label, blinded-endpoint, randomized, controlled, phase 3 trial. The primary objective of this study is to explore the efficacy and safety of the dose of 0.25 mg/kg tenecteplase (TNK) in Chinese acute ischemic stroke (AIS) patients without substantial infarction on non-contrast computed tomography (NCCT) in an extended time window.
Trial Details
NCT Number NCT06994975
Lead Sponsor Huashan Hospital
Conditions
(from sponsor)		 Acute Ischemic Stroke
Related terms Ischemic Stroke
Enrollment 890 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov