Assessing CSF Flow Dynamics in Pediatric Hemorrhagic Hydrocephalus

The purpose of this study is to evaluate the safety and efficacy of ventricular microdosing of indocyanine green (ICG) in order to assess cerebrospinal fluid (CSF) ventricular dynamics and extracranial CSF outflow using fluorescent Cap-based Transcranial Optical Tomography (fCTOT) and Near-InfraRed Fluorescent (NIRF) imaging and to evaluate inflammation markers of the CSF and to correlate with CSF ventricular dynamics, extracranial outflow into the lymphatics, ventriculomegaly, and patient's clinical outcome in order to understand how inflammation may impact that status of extracranial outflow.

NCT Number	NCT06994949
Lead Sponsor	Eva Sevick Collaborators: National Institute of Neurological Disorders and Stroke (NINDS)
Conditions	Post-hemorrhagic Hydrocephalus (PHH)
Enrollment	20 participants
Start Date	2025-01-14
Primary Completion	2029-01-03 (estimated)
Study Completion	2029-01-03 (estimated)
Updated on ClinicalTrials.gov	2025-05-29