Clinical Trial

Study of Corneal Biomechanics in Glaucoma Patients Using Brillouin Microscopy

Recruiting
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Summary
This pilot study evaluates the biomechanical properties of the cornea in glaucoma patients using Brillouin microscopy, a non-contact imaging technique. The study aims to compare corneal stiffness between patients with normal-tension glaucoma, high-tension glaucoma, and healthy controls, and to assess changes in corneal biomechanics following intraocular pressure (IOP)-lowering treatment. The goal is to determine whether Brillouin-derived biomechanical measurements can serve as biomarkers for glaucoma risk and progression.
Protocol Amendment History 2 changes
notable Primary completion pushed: 2026-03 -> 2027-03 2026-08-11
minor Completion pushed: 2026-06 -> 2027-06 2026-08-11
Trial Details
NCT Number NCT06993597
Lead Sponsor University of Maryland, Baltimore
Collaborators: National Eye Institute (NEI)
Conditions Glaucoma
Enrollment 60 participants
Start Date 2025-09-01
Primary Completion 2027-03 (estimated)
Study Completion 2027-06 (estimated)
Updated on ClinicalTrials.gov 2026-08-10