The Brain&Senses Study

The aim of this longitudinal observational study is to evaluate the impact of sensory deficits (smell, hearing and balance on cognitive decline and quality of life in the medium term (5 years)) on a population of patients over 55. Patients will be evaluated by a neurologist, a neuropsychologist and an otolaryngologist who will perform olfactory, auditory and vestibular tests. The acquired data will then be analyzed with multivariate analysis to understand the effect of multisensory deficit on both cognition and quality of life with a particular focus on depression. The primary objective will be the evaluation of multiple deficits on cognition, the secondary will be aimed at understanding whether one sensory deficit more than another, e.g. smell versus hearing, will have a greater impact on the patient's conditions.

NCT Number	NCT06991816
Lead Sponsor	University of Campania Luigi Vanvitelli Collaborators: Ospedali Riuniti Marche Nord, Fano-Pesaro Hospital
Conditions	Mild Cognitive Impairment, Alzheimer Disease, Parkinson
Enrollment	100 participants
Start Date	2025-08-01
Primary Completion	2026-08-31 (estimated)
Study Completion	2031-06-30 (estimated)
Updated on ClinicalTrials.gov	2026-04-23