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Effect of EIT-guided PEEP in ARDS Patients

StatusRecruiting
PhaseNot applicable
Started
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Record History

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  1. Primary completion pushed from Jan 19, 2029 to Dec 31, 2029v6 Show 4 more changesShow less
    • Trial sites expanded: 3 → 17 locations
    • Study completion pushed from Feb 20, 2029 to Feb 20, 2030
    • Start date changed from estimate of May 13, 2026 to Mar 13, 2026
    • Eligibility criteria shortened, about 16 words
  2. Enrollment increased: 264 → 2400 participants
    • Start date: Jan 28, 2026 to May 13, 2026
    • Eligibility criteria shortened, about 20 words
    • Study title shortened, about 3 words
    v5
  3. Start date changed from estimate of Jan 20, 2026 to Jan 28, 2026
    • Study title shortened, about 4 words
    v4
  4. Trial status: Not Yet Recruiting to Recruitingv3 Show 4 more changesShow less
    • Primary completion date: Dec 31, 2025 to Jan 19, 2029
    • Start date: Dec 1, 2025 to Jan 20, 2026
    • Study sites: 0 to 3
    • Study completion date: Feb 20, 2026 to Feb 20, 2029
  5. Enrollment target: 60 to 264
    • Start date: Jun 1, 2025 to Dec 1, 2025
    • Eligibility criteria shortened, about 12 words
    • Study title shortened, about 1 word
    v2
  6. Study First Submitted
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
Acute respiratory syndrome distress (ARDS) is a clinical common syndrome with high mortality. Mechanical ventilation (MV) is the cornerstone of management of ARDS but can lead to ventilator-induced lung injury. Positive end-expiratory pressure (PEEP), as one of main component of MV, has been widely used in the clinical practice. However, the PEEP selection is still a difficult problem for moderate to severe ARDS patients. EIT, an imaging tool evaluating the regional ventilation distribution at the bedside, can achieve the individual PEEP selection for all mechanically ventilated patients. Our previous study found that moderate to severe ARDS patients with higher recruitability could benefit from EIT-guided PEEP. This article compared the effect of PEEP titrated guided by EIT with fraction of inspired oxygen (FiO2)-PEEP table on the clinical outcomes in ARDS patients.
Trial Details
NCT Number NCT06990477
Lead Sponsor Southeast University, China
Conditions
(from sponsor)		 ARDS (Acute Respiratory Distress Syndrome)
Related terms Acute Lung Injury
Enrollment 2,400 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov