Effect of EIT-guided PEEP in ARDS Patients

Acute respiratory syndrome distress (ARDS) is a clinical common syndrome with high mortality. Mechanical ventilation (MV) is the cornerstone of management of ARDS but can lead to ventilator-induced lung injury. Positive end-expiratory pressure (PEEP), as one of main component of MV, has been widely used in the clinical practice. However, the PEEP selection is still a difficult problem for moderate to severe ARDS patients. EIT, an imaging tool evaluating the regional ventilation distribution at the bedside, can achieve the individual PEEP selection for all mechanically ventilated patients. Our previous study found that moderate to severe ARDS patients with higher recruitability could benefit from EIT-guided PEEP. This article compared the effect of PEEP titrated guided by EIT with fraction of inspired oxygen (FiO2)-PEEP table on the clinical outcomes in ARDS patients.

NCT Number	NCT06990477
Lead Sponsor	Southeast University, China
Conditions	ARDS (Acute Respiratory Distress Syndrome)
Enrollment	2,400 participants
Start Date	2026-03-13
Primary Completion	2029-12-31 (estimated)
Study Completion	2030-02-20 (estimated)
Updated on ClinicalTrials.gov	2026-07-10