Comparative Effectiveness of Different Techniques for Repeat Ablation of Atrial Fibrillation

Atrial fibrillation (AF) is the most common type of irregular heartbeat doctors see. People with AF sometimes have a procedure called an ablation to help get their heart back into a normal rhythm. However, this treatment doesn't always work. This study is looking at whether adding an extra step to the usual ablation-specifically treating another area of the heart called the left atrial (LA) posterior wall-can help people feel better overall, compared to just repeating the standard pulmonary vein isolation ablation procedure.

NCT Number	NCT06988202
Lead Sponsor	University of Rochester Collaborators: Patient-Centered Outcomes Research Institute
Conditions	Atrial Fibrillation (AF)
Enrollment	630 participants
Start Date	2026-03-18
Primary Completion	2030-01-01 (estimated)
Study Completion	2031-12-31 (estimated)
Updated on ClinicalTrials.gov	2026-03-23