Dexamethasone Palmitate for PONV After Craniotomy

Dexamethasone is almost one of the most commonly used drugs for postoperative nausea and vomiting (PONV) prevention. However, PONV is still a complex problem to be solved; for example, even with preoperative dexamethasone administration, there are still some patients undergoing craniotomy still experience PONV within 24 hours postoperatively. Compared to dexamethasone, dexamethasone palmitate has a long-lasting anti-inflammatory effect, 2-5 times that of traditional water-soluble dexamethasone, with fewer adverse effects. This trial aims to assess the effect and safety of preoperative dexamethasone palmitate on PONV after craniotomy.

NCT Number	NCT06988124
Lead Sponsor	Beijing Tiantan Hospital
Conditions	Postoperative Nausea and Vomiting
Enrollment	500 participants
Start Date	2025-06-25
Primary Completion	2027-05-01 (estimated)
Study Completion	2027-06-01 (estimated)
Updated on ClinicalTrials.gov	2025-09-23