"Pseudo-scanner" MRI Sequences for the Detection of Bone Lesions in Multiple Myeloma

Recent work has confirmed the diagnostic performance of pseudo-CT sequences for detecting osteolytic lesions. Their integration into whole body MRI (WB MRI) could transform the diagnostic approach to MM, by allowing a combined assessment of bone marrow involvement, tissue viability and osteolysis, during a single non-irradiating imaging examination. Since the preliminary work mentioned above, optimizations have been made to the pseudo-CT sequences, including the addition of deep learning (correcting noise in the images) and the correction of chemical shift artifact (linked to the coexistence of hydrated tissue and fatty tissue), which carry real hope of improving their diagnostic potential and accuracy.

NCT Number	NCT06988020
Lead Sponsor	Cliniques universitaires Saint-Luc- Université Catholique de Louvain Collaborators: General Electric
Conditions	Multiple Myeloma Bone Disease
Enrollment	45 participants
Start Date	2025-04-22
Primary Completion	2027-11 (estimated)
Study Completion	2027-11 (estimated)
Updated on ClinicalTrials.gov	2026-04-24