Clinical Trial

tdCS Combined With Treadmill Training in Patients With Multiple Sclerosis

Study acronym: TDCS

Recruiting

Record status

This record was last updated May 29, 2025 (before its estimated August 31, 2025 completion). Its status may not reflect the trial's current state.

Summary

This clinical trial aims to evaluate the therapeutic effectiveness of transcranial direct current stimulation (tDCS), a non-invasive technique that modulates cortical excitability, in combination with gait training in patients with multiple sclerosis (MS). The study focuses on improving balance and walking ability, which are commonly impaired in this population. A randomized, triple-blind, controlled design will be used, comparing an active tDCS group with a sham stimulation group, both receiving the same gait training protocol. Outcomes will include functional and clinical measures related to mobility, balance, and fatigue. The project builds on previous meta-analytical evidence suggesting positive effects of tDCS in MS and aims to confirm these findings using an optimized stimulation protocol.

Protocol Amendment History 1 amendment

This ClinicalTrials.gov record has been amended once since 2025-05-15.

Status change: Enrolling by Invitation → Recruiting 2025-05-22

Trial Details

NCT Number	NCT06986278
Lead Sponsor	University of Castilla-La Mancha Collaborators: Asociación Esclerosis Múltiple de Toledo, España
Conditions	tDCS, Sham tDCS
Enrollment	78 participants
Start Date	2025-05-26
Primary Completion	2025-08-31 (estimated)
Study Completion	2025-12-31 (estimated)
Updated on ClinicalTrials.gov	2025-05-29