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Comparing Antibiotic Treatment Strategies for Children With Pneumonia in Outpatient Settings: (STAMPP)

Study acronym: STAMPP
StatusRecruiting
PhaseNot applicable
Started
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Record History

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  1. Minor Secondary endpoints: details revised at 1 of 5 entries
    • Site details revised at 1 of 4 sites
    • Eligibility criteria expanded, about 1 word
    v5
  2. Minor Start date changed from estimate of Aug 30, 2025 to Sep 9, 2025v4
  3. Minor Site details revised at 2 of 4 sitesv3
  4. Notable Trial status: Not Yet Recruiting to Recruiting
    • Site details revised at 4 of 4 sites
    v2
  5. Minor Study First Submitted
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
The goal of this clinical trial is to determine if a "watch and wait" antibiotic strategy, called Safety Net Antibiotic Prescribing (SNAP), can safely reduce unnecessary antibiotic use while ensuring that children diagnosed with community-acquired pneumonia get better from their illness. The main aims of this study are: * To compare the effectiveness of SNAP versus immediate antibiotic prescribing in children with mild community-acquired pneumonia (CAP) * To identify which patient groups benefit most from the SNAP strategy * To identify factors that shape implementation of each prescribing strategy. Researchers will compare the SNAP strategy (where parents or guardians are instructed to give antibiotics only if their child is not improving after 72 hours, or sooner if they are worsening) to the immediate antibiotic prescribing strategy (where parents or guardians are instructed to give the antibiotics right after their healthcare visit) to see if one strategy is more effective than the other. Participants will be randomly assigned to either the immediate antibiotic group or the SNAP group at enrollment. Participation lasts 14 days with follow-up surveys at 4, 7, and 14 days after enrollment.
Trial Details
NCT Number NCT06986148
Lead Sponsor Ann & Robert H Lurie Children's Hospital of Chicago
Collaborators: Patient-Centered Outcomes Research Institute
Conditions
(from sponsor)
Community Acquired Pneumonia (CAP), Community Acquired Pneumonia
Related terms Community-Acquired Pneumonia, Pneumonia
Enrollment 2,000 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov