Vascular Function and Oxidative Stress in Emergency Medical Responders

The goal of this clinical trial is to characterize blood vessel function and oxidative stress (a harmful condition that damages cells and tissues) in emergency medical technicians (EMTs). The main questions it aims to answer are: 1. Does an overnight shift work in emergency medical technicians reduce blood vessel function and increase oxidative stress? 2. Can supplementing with antioxidants help reduce the negative effects of night shift work in emergency medical technicians? Researchers will compare antioxidants to a placebo (a look-alike substance that contains no drug) to see if antioxidants work in reducing the negative effects of night shift work in emergency medical technicians. Participants will: 1\. Report to the lab two separate times following an overnight shift to assess blood vessel functioning and oxidative stress 3. Take an antioxidant supplement or placebo during each night of shift work.

NCT Number	NCT06985394
Lead Sponsor	University of Delaware
Conditions	Cardiovascular Function in EMTs
Enrollment	45 participants
Start Date	2025-05-14
Primary Completion	2025-09 (estimated)
Study Completion	2025-10 (estimated)
Updated on ClinicalTrials.gov	2025-05-22