Urgent Panendoscopy in Patients Presenting With Hematochezia

Gastrointestinal bleeding is a significant emergency condition requiring prompt diagnosis. Current evidence presents a clinical paradox: urgent colonoscopy (within 24 hours) shows no clear benefit in several studies, while urgent video capsule endoscopy (VCE) demonstrates improved detection rates for small bowel bleeding. This study aims to evaluate a novel approach combining urgent colonoscopy followed by same-day VCE for patients with normal colonoscopy findings. This strategy has not been previously assessed and may improve bleeding source detection while reducing patient preparation burden compared to standard sequential testing. Results will be compared against conventional approaches to determine optimal diagnostic timing for patients presenting with hematochezia

NCT Number	NCT06985277
Lead Sponsor	Mahidol University
Conditions	Lower Gastrointestinal Bleeding, Small Bowel Bleeding
Enrollment	188 participants
Start Date	2024-04-09
Primary Completion	2024-04-09 (estimated)
Study Completion	2028-01 (estimated)
Updated on ClinicalTrials.gov	2025-05-30