Clinical Trial

Evaluation of Ventilation Defects Downstream of Mucus Plugs in Patients With Muco-Obstructive Lung Disease

Recruiting
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Summary
In this study, xenon MRI will be used to evaluate regional functional consequences of mucus plugs in the lungs of patients with muco-obstructive pulmonary disease. Mucus plugs will be identified using CT imaging, and xenon MRI will be used to evaluate ventilation and gas exchange impairments in regions of the lungs corresponding to the airways downstream of mucus plugs.
Protocol Amendment History 1 change
notable Enrollment increased: 5 -> 8 participants 2026-07-02
Trial Details
NCT Number NCT06985225
Lead Sponsor University of Kansas Medical Center
Collaborators: Polarean Imaging, Plc
Conditions Severe Asthma, COPD, Non-CF Bronchiectasis, Cystic Fibrosis (CF)
Enrollment 8 participants
Start Date 2025-06-01
Primary Completion 2026-12 (estimated)
Study Completion 2026-12 (estimated)
Updated on ClinicalTrials.gov 2026-07-01