Clinical Trial

Study of Craniospinal Irradiation With Linac Based Volumetric Modulated Arc Therapy (VMAT) for Patients With Leptomeningeal Metastasis

Active, Not Recruiting
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Summary
The purpose of this study is to confirm the safety and efficacy of linac based Volumetric Modulated Arc Therapy (VMAT) for craniospinal irradiation (CSI) in solid tumor cancer patients with leptomeningeal metastasis. The primary aim is to determine if linac based VMAT CSI for leptomeningeal metastasis improves central nervous system (CNS) progression free survival (PFS) compared to the historical standard control CNS PFS in patients treated with Involved Field Radiation Therapy (IFRT).
Protocol Amendment History 2 amendments
This ClinicalTrials.gov record has been amended 2 times since 2025-05-14; most recent amendment 2026-03-30.
Status change: Not Yet Recruiting → Active, Not Recruiting 2026-03-30
Trial Details
NCT Number NCT06984523
Lead Sponsor NYU Langone Health
Conditions Leptomeningeal Metastasis
Enrollment 20 participants
Start Date 2025-05-14
Primary Completion 2028-05-12 (estimated)
Study Completion 2028-05-12 (estimated)
Updated on ClinicalTrials.gov 2026-03-31