Randomized Trial Comparing Fecal Testing (FIT) to Colonoscopy for Post-polypectomy Surveillance

From observational studies, it is know that the risk of developing colorectal cancer after polyp removal is lower if the patients adheres to surveillance recommendations. However, colonoscopy is burdensome for patients and colonoscopy availability is limited in many parts of the world. In addition, more than half of surveillance colonoscopies are without any findings. The trial investigates whether surveillance using fecal testing for blod is as good as colonoscopy after removal of colorectal polyps.

NCT Number	NCT06983639
Lead Sponsor	Sorlandet Hospital HF Collaborators: Sykehuset Ostfold, University Hospital, Akershus, Vestre Viken Hospital Trust, Sykehuset Telemark Hospital Trust, Helse Møre og Romsdal HF, St. Olavs Hospital, University Hospital of North Norway, Sykehuset i Vestfold HF, Helse Stavanger HF, Turku University Hospital, Helsinki University Central Hospital, Randers Regional Hospital, Viborg Regional Hospital, Gødstrup Hospital, Horsens Hospital
Conditions	Colorectal Neoplasms
Enrollment	4,000 participants
Start Date	2026-01-09
Primary Completion	2040-12-31 (estimated)
Study Completion	2050-01-01 (estimated)
Updated on ClinicalTrials.gov	2026-01-15