Predictive Utility and Mechanisms of Sacral Evoked Responses in Sacral Neuromodulation

Electrical stimulation of the sacral nerve can help with bladder problems and pelvic pain but researchers don't understand exactly how the stimulation helps. The goal of this study is to examine signals evoked during sacral neuromodulation (SNM or electrical stimulation of the sacral nerve) and their relationship to the selection of stimulation parameters that improve pelvic function symptoms. This study uses SNM parameters based on visual-motor responses (VMR) or sacral evoked responses (SER). It is investigating how the parameter selection impacts change in bladder function.

NCT Number	NCT06983470
Lead Sponsor	University of Michigan Collaborators: Medtronic
Conditions	Overactive Bladder
Enrollment	15 participants
Start Date	2025-10-16
Primary Completion	2028-09 (estimated)
Study Completion	2029-10 (estimated)
Updated on ClinicalTrials.gov	2025-12-18