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The Effects of Propranolol and Hydrocortisone on Military-Relevant Performance Outcomes

StatusRecruiting
PhasePhase 4
Started
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Record status
This record was last updated May 13, 2026 (before its estimated September 2026 completion). Its status may not reflect the trial's current state.

Record History

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  1. Enrollment target: 110 to 88v3 Show 6 more changesShow less
    • Interventions: Hydrocortisone (Drug), Morphine (Drug), Placebo (IM) (Drug), Placebo (oral) (Drug), Propranolol (Drug) to Hydrocortisone (Drug), Placebo (IM) (Drug), Placebo (oral) (Drug), Propranolol (Drug)
    • Secondary endpoints: 14 to 13
    • Site contact updated
    • Study arms: 5 to 4
    • Eligibility criteria shortened, about 3 words
    • Study title shortened, about 1 word
  2. Start date changed from estimate of May 2025 to May 27, 2025
    • Eligibility criteria shortened, about 13 words
    v2
  3. Study First Submitted
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
This clinical trial aims to evaluate the nature and duration of effects of three FDA-approved medications (propranolol and hydrocortisone) on military-relevant cognitive, emotional, and motor performance following an exposure to a stressful situation (i.e., exposure to a tarantula) in physically healthy adult volunteers (aged 18 - 40) with fear of spiders to help the future development of medications for treating Acute Stress Reactions. The main questions this study aims to answer are: Will placebo treatment (oral placebo) result in significant decrements in Psychomotor Vigilance Task (PVT) performance compared to propranolol treatment? Will placebo treatment \[intramuscular (IM) placebo\] result in significant decrements in PVT performance compared to hydrocortisone treatment? Participants will receive one of five study medications (oral propranolol, oral placebo, IM hydrocortisone, or IM placebo) after a brief exposure to a tarantula. Participants will complete cognitive and simple motor tasks and psychological assessments before and after the study medication administration.
Trial Details
NCT Number NCT06982183
Lead Sponsor Walter Reed Army Institute of Research (WRAIR)
Conditions
(from sponsor)		 Fear of Spiders, Acute Stress Reaction
Related terms Arachnophobia, Stress Disorders, Traumatic, Acute
Enrollment 88 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov