Hyaluronidase Enzymes and Local Anesthesia

* For both groups, local anaesthesia will be administered by one single surgeon and the extraction will be performed by another single surgeon across all subjects. The surgeon performing the extraction will be blinded with regard to the local anaesthesia technique used in this study * A buccal infiltration injection of 1.5 ml of 4% articaine with 1:100,000 adrenaline (Septocaine, Septodont, New Castle, Del.) plus 1.5 ml of hyaluronidase enzyme (7.5IU/1ml) will be used in the study group while use 4% articaine with 1:100,000 adrenaline (Septocaine, Septodont, New Castle, Del.)only in traditional inferior alveolar nerve block in the control group * In study and control groups, VAS (visual analogue scale=is an unmarked, continuous, horizontal,100-mm line, anchored by the end points of "no pain" on the left and "worst pain" on the right ) will be used to evaluate the pain levels of the patients associated with the injection and during extraction

NCT Number	NCT06980363
Lead Sponsor	Fayoum University
Conditions	Local Infiltration
Enrollment	20 participants
Start Date	2025-06-01
Primary Completion	2025-08-01 (estimated)
Study Completion	2025-08-27 (estimated)
Updated on ClinicalTrials.gov	2025-05-20