Neural Mechanisms of Interpersonal Expectations on Negative Affect

The goal of this clinical trial is to learn whether non-invasive brain stimulation, called transcranial temporal interference stimulation (tTIS), can reduce negative affect, and how expectations shaped by care providers influence these effects. The main questions this study aims to answer are: (1)Does active tTIS reduce negative affect more effectively than sham (inactive) tTIS? (2)Do positive treatment expectations enhance the effects compared to negative expectations? Participants will: (1) Receive either active or sham tTIS. (2) Be provided with positive or negative messaging regarding treatment effectiveness. (3) Interact with care providers and complete assessments measuring negative affect and physiological responses.

NCT Number	NCT06980090
Lead Sponsor	Trustees of Dartmouth College
Conditions	Negative Affectivity, Non-invasive Brain Stimulation, Placebo Effect, Expectations
Enrollment	196 participants
Start Date	2025-09-01
Primary Completion	2027-08-31 (estimated)
Study Completion	2028-03-03 (estimated)
Updated on ClinicalTrials.gov	2026-06-11