Clinical Trial

Investigating Multigene Methylation Dynamics in Treatment Response Surveillance for Esophageal Carcinoma

Recruiting
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Summary
The primary objective is to determine whether pretreatment-to-posttreatment changes in circulating multigene methylation levels correlate with objective response rates (ORR) assessed by contrast-enhanced CT/MRI and levels of serum tumor markers. Secondary endpoints include: (a) time-dependent association between methylation fluctuation patterns and progression-free survival (PFS), (b) comparative diagnostic accuracy of methylation indices versus conventional biomarkers, and (c) feasibility of using methylation thresholds to guide adaptive therapy modification.
Protocol Amendment History 1 amendment
This ClinicalTrials.gov record has been amended once since 2025-05-18.
Status change: Not Yet Recruiting → Recruiting 2025-12-14
Trial Details
NCT Number NCT06979869
Lead Sponsor Xijing Hospital
Conditions Esophageal Cancer
Enrollment 300 participants
Start Date 2025-05-26
Primary Completion 2030-03-01 (estimated)
Study Completion 2030-03-01 (estimated)
Updated on ClinicalTrials.gov 2025-12-16