Research for Plasma Biomarkers Associated With Fatigue in Thrombocytopenic Patients

Thrombocytopenia is a clinical problem defined by a platelet count lower than 150×10⁹/L. It can be linked to various pathologies of central origin, such as decreased platelet production in the bone marrow, or peripheral origin with increased platelet destruction through autoimmune mechanisms, increased splenic sequestration, or excessive platelet consumption. Significant fatigue is often reported in association with thrombocytopenia, but its underlying pathophysiology remains unclear. One hypothesis is the role played by neurotrophic factors contained in platelets and released into the circulation following their activation, in particular the Brain-Derived Neurotrophic Factor (BDNF), which promotes the survival, growth, differentiation, and plasticity of neurons in both the central and peripheral nervous systems. Consequently, BDNF plays a key role in long-term memory, intellectual abilities, and neuroprotection. In this context, this project aims to confirm whether platelet-origin neurotrophic biomarkers could explain the fatigue experienced by thrombocytopenic patients and whether it depends on the etiology of the thrombocytopenia.

NCT Number	NCT06979765
Lead Sponsor	Assistance Publique - Hôpitaux de Paris
Conditions	Thrombopenia
Enrollment	280 participants
Start Date	2025-03-26
Primary Completion	2028-03-26 (estimated)
Study Completion	2028-06-26 (estimated)
Updated on ClinicalTrials.gov	2026-02-03