Impact of Genetic Polymorphisms And DASH Diet On Weight Loss Progression In Climacteric Women With Metabolic Syndrome

Metabolic syndrome is a multifactorial inflammatory condition that is very prevalent in overweight women with type 2 diabetes. However, there seems to be great benefit in changing lifestyle and dietary patterns in the treatment of this condition. Currently, few studies have shown the effect of a Dietary Approach to Stop Hypertension (DASH) diet in postmenopausal women with metabolic syndrome and the influence of genetic polymorphisms of the fat mass and obesity-associated protein (FTO) and beta-2 adrenergic receptor (ADRB2) genes on inflammatory markers and improvement of laboratory indicators in these patients. This study aims to analyze the interaction of polymorphisms in the ADRB2 and FTO genes and the DASH diet on anthropometric indicators and laboratory tests in patients with metabolic syndrome in the city of Rio de Janeiro. For this purpose, laboratory tests and anthropometric data will be collected in a prospective study with women aged between 40 and 60 years.

NCT Number	NCT06978504
Lead Sponsor	Nutrindo Ideais Research Center Collaborators: Universidade Federal do Rio de Janeiro
Conditions	Nutrition, Metabolic Syndrome, Obesity, Weight Loss, Genetic Polymorphisms
Enrollment	30 participants
Start Date	2025-04-01
Primary Completion	2025-08-01 (estimated)
Study Completion	2026-08-03 (estimated)
Updated on ClinicalTrials.gov	2026-08-04