Clinical Trial

Effect of Non-Selective Beta-Blockers on Outcomes in Cirrhosis Patients After Hospitalization: A Retrospective Cohort Using Target Trial Design

Active, Not Recruiting
View on ClinicalTrials.gov →
Summary
The goal of this observational study is to learn if non-selective beta-blockers (NSBB) improve outcomes in patients with chronic hepatitis B or C who are discharged after hospitalization for acute decompensation of cirrhosis. The main questions it aims to answer are: 1. Does NSBB use at discharge reduce mortality rates in cirrhotic patients with hepatic complications? 2. Does NSBB use at discharge decrease hospital readmission rates? Researchers will compare patients discharged with NSBB prescriptions to those without NSBB to see if NSBB use decreases mortality and readmission rates. Participants were patients hospitalized for hepatic complications (hepatic encephalopathy, hepatorenal syndrome, ascites, or spontaneous peritonitis) between January 2013 and October 2023, with data analyzed retrospectively using a target trial emulation design.
Trial Details
NCT Number NCT06977685
Lead Sponsor Samsung Medical Center
Conditions Cirrhosis, Decompensated Cirrhosis of Liver
Enrollment 7,725 participants
Start Date 2013-01-01
Primary Completion 2023-10-31 (estimated)
Study Completion 2025-12-31 (estimated)
Updated on ClinicalTrials.gov 2025-05-18