Appropriateness of Antibiotic Combination Therapy for Severe Community-acquired Pneumonia in South Korea

This study aims to provide high-level evidence for appropriate empirical antibiotic use tailored to the clinical reality in Korea by conducting a randomized controlled trial comparing monotherapy with piperacillin/tazobactam and combination therapy with piperacillin/tazobactam plus a fluoroquinolone in patients with severe community-acquired pneumonia.

NCT Number	NCT06977347
Lead Sponsor	CHOSEOK YOON
Conditions	Severe Community-acquired Pneumonia (sCAP)
Enrollment	100 participants
Start Date	2025-06-15
Primary Completion	2026-12-31 (estimated)
Study Completion	2027-02-01 (estimated)
Updated on ClinicalTrials.gov	2025-05-18