Metacognitive Therapy vs Unified Protocol for Patients With Comorbid Anxiety Disorders

The primary goal of this randomized controlled trial is to compare the effectiveness of two transdiagnostic psychological treatments, Metacognitive Therapy (MCT) and the Unified Protocol for Transdiagnostic Treatment of Emotional Disorders (UP), for patients with complex anxiety.

NCT Number	NCT06971692
Lead Sponsor	Karolinska Institutet Collaborators: Region Stockholm
Conditions	Posttraumatic Stress Disorder (PTSD), Generalized Anxiety Disorder (GAD), Social Anxiety Disorder (SAD), Panic Disorder (With or Without Agoraphobia)
Enrollment	114 participants
Start Date	2025-08
Primary Completion	2027-12 (estimated)
Study Completion	2028-12 (estimated)
Updated on ClinicalTrials.gov	2025-05-14