Impact of Vitamin C on Pain Detection and Tolerance Threshold

Non-opioid treatments are increasingly sought after for managing acute pain. Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) (e.g., Advil, Motrin, Naproxen) combined with acetaminophen (e.g., Tylenol) have become an alternative for relieving acute pain. However, many patients cannot tolerate or have contraindications to NSAIDs and acetaminophen. There is therefore an urgent need for studies evaluating the analgesic effects of vitamin C in the context of acute pain. Our study is conducted with healthy volunteer participants receiving either vitamin C or a placebo to assess the analgesic effect of vitamin C by comparing pain detection and tolerance thresholds.

NCT Number	NCT06971315
Lead Sponsor	Centre Integre Universitaire de Sante et Services Sociaux du Nord de l'ile de Montreal
Conditions	Pain, Acute
Enrollment	38 participants
Start Date	2025-07-18
Primary Completion	2025-08-06 (estimated)
Study Completion	2025-12-19 (estimated)
Updated on ClinicalTrials.gov	2026-03-31