Fermented Milk Drink With Lacticaseibacillus Paracasei Strain Shirota Helps Triathletes With Cold-Like Symptoms Before and After a Race

This study aims to evaluate whether a fermented milk drink containing the probiotic strain Lacticaseibacillus paracasei strain Shirota (LCS), commonly found in Yakult®, can help reduce upper respiratory symptoms in triathletes before and after competition. Athletes often experience cold-like symptoms due to physical stress, intense training, and immune system challenges. The study investigates whether daily consumption of this probiotic drink can help improve immune response and reduce the incidence or severity of symptoms such as sore throat, nasal congestion, or coughing. This is a randomized, double-blind, placebo-controlled, parallel-group study involving healthy adult triathletes. Participants will be randomly assigned to receive either the probiotic drink or a placebo for a specific period before and after a triathlon event. Symptoms and health markers will be tracked through questionnaires and biological samples. The goal is to explore whether probiotic supplementation can provide practical, non-pharmacological support for athletes' immune health and well-being during intense physical activity.

NCT Number	NCT06970964
Lead Sponsor	Federal University of São Paulo
Conditions	Respiratory Tract Infections (RTI), Mucosal Immunity, Systemic Inflammation, Depressive Disorder, Exercise-Induced Immunosuppression, Athletic Performance, Upper Respiratory Tract Symptoms, Mental Health +2 more
Enrollment	80 participants
Start Date	2025-08-13
Primary Completion	2025-08-21 (estimated)
Study Completion	2025-11-05 (estimated)
Updated on ClinicalTrials.gov	2026-01-15