Transcranial Electrical Stimulation in Multiple Sclerosis

First the investigators will examine if the blood flow in the brain is different in patients with Multiple Sclerosis compared to healthy volunteers. HOW? \- The blood flow of the subjects is imaged by use of a special MRI-technique. Secondly, the investigators will examine if the blood flow can determine disease progression. HOW? - Multiple Sclerosis patients are asked for a follow-up visit after two years. The main goal is to understand the effect of transcranial Direct Current Stimulation (tDCS) on the cerebral blood flow. * Does tDCS result in a different blood flow, in which brain regions? * Is there a difference between healthy volunteers and Multiple Sclerosis patients? HOW? \- Participants get two session of tDCS. Before, during and after stimulation MRI scans are performed.

NCT Number	NCT06966128
Lead Sponsor	Universitair Ziekenhuis Brussel Collaborators: Fund for Scientific Research, Flanders, Belgium, Vrije Universiteit Brussel
Conditions	Multiple Sclerosis
Enrollment	100 participants
Start Date	2025-06-01
Primary Completion	2029-01-01 (estimated)
Study Completion	2029-01-01 (estimated)
Updated on ClinicalTrials.gov	2025-05-29