Clinical Trial

Rebound Pain After Peripheral Nerve Blocks in Total Knee Arthroplasty

Completed
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Summary
This prospective observational study aims to determine the incidence and clinical impact of rebound pain after peripheral nerve blocks in patients undergoing total knee arthroplasty. Rebound pain is defined as a sudden, severe pain (NRS ≥7) emerging after block resolution. Primary outcome is the incidence of rebound pain; secondary outcomes include pain severity, rescue analgesia use, nausea, vomiting, sleep quality, and patient satisfaction.
Protocol Amendment History 3 amendments
This ClinicalTrials.gov record has been amended 3 times since 2025-05-02; most recent amendment 2026-03-30.
Status change: Recruiting → Completed 2026-03-30
Status change: Not Yet Recruiting → Recruiting 2025-05-21
Trial Details
NCT Number NCT06966011
Lead Sponsor Konya City Hospital
Conditions Total Knee Arthroplasty, Postoperative Pain, Rebound Pain, Peripheral Nerve Block, Pain Management
Enrollment 294 participants
Start Date 2025-05-21
Primary Completion 2026-03-03 (estimated)
Study Completion 2026-03-03 (estimated)
Updated on ClinicalTrials.gov 2026-04-03