Clinical Trial

Comparison of Recurrence Rate of Keloid After Excision Between Intra-operative Steroid Injection and Steroid With Platelet-rich Plasma Injection Combination Therapy

Active, Not Recruiting Phase 2
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Record status
This record was last updated May 11, 2025 (before its estimated June 30, 2026 completion). Its status may not reflect the trial's current state.
Summary
Keloid scars are benign skin lesions characterized by excessive collagen deposition, and their treatment remains challenging due to a high recurrence rate even after surgical excision. Combination therapies have been shown to be more effective than monotherapy. A common approach for treating recurrent keloids is surgical excision followed by intralesional corticosteroid injection; however, recurrence rates remain substantial. This study was conducted to evaluate the recurrence rate of keloid scars following surgical excision combined with intralesional corticosteroid and platelet-rich plasma (PRP) injection, compared to corticosteroid injection alone administered intraoperatively.
Trial Details
NCT Number NCT06965088
Lead Sponsor Ramathibodi Hospital
Conditions Patients With Keloid Scar
Enrollment 212 participants
Start Date 2025-04-28
Primary Completion 2026-06-30 (estimated)
Study Completion 2026-09-30 (estimated)
Updated on ClinicalTrials.gov 2025-05-11