Microplastics and Nanoplastics (MNPs) in Patients With ST-elevation Myocardial Infarction (STEMI)

Air pollution and microplastics pose major public health threats. Emerging data have shown that micro- and nanoplastics (MNPs) are ubiquitous environmental pollutants accumulating in human tissues, triggering inflammation and prothrombotic state. This study will investigate the presence and burden of MNPs within coronary thrombi/thromboaspirate of patients presenting with ST segment elevation acute myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention and their association with cardiac damage, plaque vulnerability, microvascular obstruction, and cardiovascular events. Plaque vulnerability will be explored by optical coherence tomography, while microvascular obstruction will be assessed by bolus thermodilution and cardiac magnetic resonance. Participants will be followed up for 1-year to evaluate whether the presence and the burden of MNPs will be associated with a higher incidence of the cardiovascular events.

NCT Number	NCT06965023
Lead Sponsor	Azienda Ospedaliera "Sant'Andrea" Collaborators: University of Campania Luigi Vanvitelli, Azienda Ospedaliera Universitaria Integrata Verona, Morgagni Pierantoni Hospital, Azienda Ospedaliera Sant'Anna e San Sebastiano, University Hospital, Catania, A.O.U. Città della Salute e della Scienza - Molinette Hospital, Niguarda Hospital, Azienda Ospedaliera Universitaria Ferrara
Conditions	ST-elevation Myocardial Infarction (STEMI), Microplastics, Nanoplastics, Pollution Exposure
Enrollment	130 participants
Start Date	2025-04-22
Primary Completion	2026-12-30 (estimated)
Study Completion	2027-12-31 (estimated)
Updated on ClinicalTrials.gov	2025-05-11