Clinical Trial

Evaluate Efficacy, Safety, Tolerability and Biodegradation of PA5346 Ocular Implant in Patients With Open-Angle Glaucoma or Ocular Hypertension

Active, Not Recruiting Phase 1
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Summary
The goal of this clinical study is to learn how effective and safe is a single administration of PA5346 Ocular Implant for the reduction of intraocular pressure in adult patients with open-angle glaucoma or ocular hypertension. It will also assess how long it takes for PA5346 Ocular Implant to dissolve in the eye.
Protocol Amendment History 4 amendments
This ClinicalTrials.gov record has been amended 4 times since 2025-04-30; most recent amendment 2026-07-06.
Status change: Recruiting → Active, Not Recruiting 2026-04-27
Status change: Not Yet Recruiting → Recruiting 2025-06-10
Trial Details
NCT Number NCT06964061
Lead Sponsor PolyActiva Pty Ltd
Conditions Open Angle Glaucoma (OAG), Ocular Hypertension (OH)
Enrollment 12 participants
Start Date 2025-06-10
Primary Completion 2027-02-15 (estimated)
Study Completion 2027-04-15 (estimated)
Updated on ClinicalTrials.gov 2026-07-07