Validation of the Sentinel Lymph Node Technique in Early-stage Ovarian Cancer (SENTOV II)

This clinical trial investigates the sentinel lymph node (SLN) technique as a less invasive alternative to conventional lymphadenectomy in patients with early-stage ovarian cancer. The primary objective is to evaluate the effectiveness, safety, and diagnostic accuracy of the SLN approach in detecting lymphatic metastases. By assessing its negative predictive value, the study aims to determine whether the SLN technique can reliably replace systematic pelvic and paraaortic lymphadenectomy. If successful, this technique could minimize surgical morbidity, shorten hospitalization stays, and lower complication rates, ultimately improving patient outcomes.

NCT Number	NCT06963268
Lead Sponsor	Instituto de Investigacion Sanitaria La Fe Collaborators: Hospital Universitario La Fe, Hospital Clinic of Barcelona, Hospital Universitario 12 de Octubre, Hospital Universitario La Paz, Hospital General Universitario Gregorio Marañon, Quirón Madrid University Hospital, Hospital of Navarra, Hospital Son Espases, Hospital Universitari de la Vall de Hebron, Hospital Universitario Fundación Jiménez Díaz, Clinica Universidad de Navarra, Universidad de Navarra
Conditions	Ovarian Neoplasms
Enrollment	200 participants
Start Date	2025-11-10
Primary Completion	2028-06 (estimated)
Study Completion	2028-06 (estimated)
Updated on ClinicalTrials.gov	2025-12-19