SCORE Study: Comparing Surgery and Rigid Collar Treatment for Odontoid Fractures in Adults Over 70

The goal of this clinical trial is to compare two treatment options-surgery or rigid collar bracing-for unstable neck fractures (odontoid fractures) in adults aged 70 years and older. These fractures are common in older adults and can significantly impact mobility, independence, and quality of life. There is currently no clear evidence to determine which treatment is better for this population. The main questions it aims to answer are: * Does surgery or conservative collar treatment lead to better improvement in daily living, measured by the Barthel Index, after 12 weeks? * What are the differences in pain, disability, and quality of life between the two treatments? The study team will compare patients who receive surgical stabilization with those who are treated with a rigid cervical collar to see which approach supports better functional outcomes and healing. Participants will: * be randomly assigned to either surgery (posterior C1-C2 screw-rod fixation) or conservative collar treatment * attend study visits at 12 weeks and 6 months * complete questionnaires on daily functioning, pain, and quality of life * undergo CT scans and other medical assessments * record collar use (for conservative group) in a diary * be monitored for any complications or changes in treatment (including crossover to surgery if needed) The study aims to include 322 participants to provide evidence on which treatment helps older adults recover better from odontoid fractures with fewer complications and improved quality of life.

NCT Number	NCT06961578
Lead Sponsor	Technical University of Munich Collaborators: St. Josefs-Hospital Wiesbaden GmbH, Medical University of Cologne, BG Trauma Center Tuebingen, RWTH Aachen University, University Hospital Heidelberg, University Hospital, Essen, BG Klinikum Bergmannstrost, Halle, Germany, Helios Klinikum Berlin-Buch, German Federal Ministry of Education and Research, Charite University, Berlin, Germany
Conditions	Odontoid Fracture, Elderly
Enrollment	322 participants
Start Date	2025-08-13
Primary Completion	2027-12-12 (estimated)
Study Completion	2028-06-01 (estimated)
Updated on ClinicalTrials.gov	2026-05-06