Study of the Determinants of Coronary Atherosclerosis in Familial Hypercholesterolemia (ATHERO-FH Study)

The goal of this study (interventional clinical research not involving a health product) is to assess the prevalence of subclinical coronary atherosclerosis diagnosed by coronary CT angiography in heart failure patients in primary prevention, across different levels of cardiovascular risk defined by coronary artery calcium (CAC) score percentiles (based on data from the MESA study): low risk (≤25th percentile for age, sex, and ethnicity), intermediate risk (25th \< CAC ≤ 75th percentile), and high risk (\>75th percentile). The Patients will attend an on-site visit at inclusion (and must undergo a coronary CT angiography within 6 months following this visit), will be contacted by phone at 1 year and 2 years, and will return for an on-site visit at 30 months.

NCT Number	NCT06960902
Lead Sponsor	Nantes University Hospital Collaborators: France 2030 program, European Union
Conditions	Familial Hypercholesterolemias, Atherosclerotic Cardiovascular Disease (ASCVD)
Enrollment	600 participants
Start Date	2025-09-25
Primary Completion	2027-03-25 (estimated)
Study Completion	2029-09-25 (estimated)
Updated on ClinicalTrials.gov	2026-03-19