Pulp Inflammatory Markers and Outcome of Pulpotomy

This is a prospective clinical study that aims to investigate the level of inflammatory mediators in the inflamed dental pulp and its potential relationship to the outcome of full pulpotomy in mature permanent teeth with carious pulp exposure. Pulp blood samples from the teeth will be collected during treatment, MMP9 levels will be recorded using Elisa kits. The teeth will be restored and followed up at 1 week, 6 months, 1, and 2 years. The teeth will be assesses both clinically and radiographically. The procedure will be success if the tooth is asymptomatic clinically and with normal periapical findings. The relationship between MMP9 level and success of treatment will be investigated.

NCT Number	NCT06960603
Lead Sponsor	King Abdullah University Hospital
Conditions	Pulpitis in Permanent Teeth, Dental Caries Extending to Pulp
Enrollment	60 participants
Start Date	2024-10-07
Primary Completion	2025-12-31 (estimated)
Study Completion	2028-12 (estimated)
Updated on ClinicalTrials.gov	2026-08-11