Clinical Trial

The Effect of Hyaluronic Acid Injection on TNF-Alpha and IL-1β in Knee Osteoarthritis

Recruiting
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Record status
This record was last updated January 9, 2026 (before its estimated January 30, 2026 completion). Its status may not reflect the trial's current state.
Summary
In this study, the effect of intra-articular HA injection therapy on pre- and post-treatment TNF-alpha and IL-1beta levels and methylation changes in blood and synovial fluid in patients with knee osteoarthritis will be determined and compared with the placebo group. In addition, the effects of HA injection on pain, functional status and quality of life will be evaluated and these effects will be related to changes in TNF-alpha and IL-1-beta.
Protocol Amendment History 2 amendments
This ClinicalTrials.gov record has been amended 2 times since 2025-05-05; most recent amendment 2026-01-08.
Status change: Not Yet Recruiting → Recruiting 2025-06-10
Trial Details
NCT Number NCT06960564
Lead Sponsor Istanbul University
Collaborators: Istanbul University - Cerrahpasa
Conditions Knee Osteoarthritis, Hyaluronic Acid
Enrollment 50 participants
Start Date 2025-05-12
Primary Completion 2026-01-30 (estimated)
Study Completion 2026-03-29 (estimated)
Updated on ClinicalTrials.gov 2026-01-09