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The Effect of Hyaluronic Acid Injection on TNF-Alpha and IL-1β in Knee Osteoarthritis

StatusRecruiting
PhaseNot applicable
Started
View on ClinicalTrials.gov ↗
Trial flagged as At Risk
Primary completion moved at least 7 months later Jan 30, 2026 → Sep 2, 2026
See other at-risk trials from Istanbul University

Record History

  1. Primary completion pushed from Jan 30, 2026 to Sep 2, 2026
    • Study completion pushed from Mar 29, 2026 to Sep 2, 2026
    v4
  2. Primary completion date: Jun 30, 2025 to Jan 30, 2026
    • Study completion date: Dec 29, 2025 to Mar 29, 2026
    v3
  3. Trial status: Not Yet Recruiting to Recruiting
    • Primary completion date: Jun 17, 2025 to Jun 30, 2025
    • Site details revised
    v2
  4. Study First Submitted
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
In this study, the effect of intra-articular HA injection therapy on pre- and post-treatment TNF-alpha and IL-1beta levels and methylation changes in blood and synovial fluid in patients with knee osteoarthritis will be determined and compared with the placebo group. In addition, the effects of HA injection on pain, functional status and quality of life will be evaluated and these effects will be related to changes in TNF-alpha and IL-1-beta.
Trial Details
NCT Number NCT06960564
Lead Sponsor Istanbul University
Collaborators: Istanbul University - Cerrahpasa
Conditions
(from sponsor)		 Knee Osteoarthritis, Hyaluronic Acid
Related terms Osteoarthritis, Knee
Enrollment 50 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov