Analysis of Salivary Proteins in Young Children as an Device to Improve Caries Risk Assessment

The goal of this observational study is to learn if the composition of salivary proteins in 3-year-old children, from communities with documented varying caries risks, can be used to identify future diagnostic predictors for caries risk. The main question to answer is: • Can the host´s salivary protein profile (expression and abundance) show a correlation with the caries prevalence between the individuals in the different study cohorts? Two cohorts of children with different documented demographic characteristics in the region of Stockholm (Sweden) will be examined. Participants will be asked to provide saliva samples and undergo clinical oral examinations conducted by trained dental practitioners.

NCT Number	NCT06957509
Lead Sponsor	Karolinska Institutet Collaborators: Folktandvården Stockholms län AB
Conditions	Early Childhood Caries (ECC)
Enrollment	100 participants
Start Date	2025-04-04
Primary Completion	2026-12 (estimated)
Study Completion	2027-12 (estimated)
Updated on ClinicalTrials.gov	2026-08-05