Clinical Trial

Impact of Collaborative Care for Pregnant Women With Opioid Use Disorder in Low-Resource Obstetric Settings

Study acronym: NEST
Enrolling by Invitation
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Summary
The investigators seek to adapt a collaborative care model (CCM) for community-based, low-resource obstetric settings and to test the effects of this adapted CCM on health outcomes among Pregnant, postpartum, and parenting person (PPPP) with Opioid use disorder (OUD) and their families. To achieve this goal, investigators will conduct a nonrandomized, Type 1 hybrid implementation-effectiveness study across 3 community-based, low-resource obstetric sites in Northwest PA, a region with rates of maternal opioid-related diagnoses 4 times higher than national averages.
Protocol Amendment History 2 amendments
This ClinicalTrials.gov record has been amended 2 times since 2025-05-01; most recent amendment 2025-10-10.
Status change: Not Yet Recruiting → Enrolling by Invitation 2025-10-10
Trial Details
NCT Number NCT06956352
Lead Sponsor University of Pittsburgh
Collaborators: Magee-Women's Research Institute, National Institute on Drug Abuse (NIDA)
Conditions Pregnancy, Postpartum Period, Opioid Use Disorder
Enrollment 1,350 participants
Start Date 2025-06-24
Primary Completion 2030-08 (estimated)
Study Completion 2031-08 (estimated)
Updated on ClinicalTrials.gov 2025-10-14