Clinical Trial

Characterizing Perceived Physical Fatigability in Nusinersen-treated SMA

Recruiting
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Summary
The purpose of this project is to investigate the utility of the SMA EFFORT, an SMA-specific patient-reported outcome measure, to assess perceived physical fatigability that is anchored to intensity and duration of activities. We aim to characterize perceived physical fatigability (PPF) in a diverse cohort of people with SMA (pwSMA) and evaluate the change of PPF before and after nusinersen dosing.
Protocol Amendment History 2 amendments
This ClinicalTrials.gov record has been amended 2 times since 2025-04-25; most recent amendment 2026-05-12.
Trial Details
NCT Number NCT06955897
Lead Sponsor Columbia University
Collaborators: Biogen
Conditions Spinal Muscular Atrophy
Enrollment 45 participants
Start Date 2025-04-24
Primary Completion 2026-12-07 (estimated)
Study Completion 2027-02-26 (estimated)
Updated on ClinicalTrials.gov 2026-05-14