Saline Versus Balanced Crystalloid in Traumatic Brain Injury

The goal of this clinical trial is to determine which crystalloid (saline or balanced) should be used in the critical management of Traumatic Brain Injury (TBI) in moderate or severe TBI patients. This trial will determine whether the use of saline or balanced crystalloids is associated with improved outcomes in TBI patients. Participants will 1. be given fluids through the veins, either saline or balanced fluid will be given. 2. From the first day to the day 14 of the hospitalization (or discharge, whichever comes first), vital signs, laboratory values, treatments given, and other medical data will be collected from the medical record. 3. Six months later, your final disability, if any, will be assessed during your follow-up with a doctor. It involves answering a short survey that will take about 5 minutes or less.

NCT Number	NCT06953674
Lead Sponsor	University of Louisville Collaborators: Kentucky Spinal Cord and Head Injury Research Board
Conditions	Traumatic Brain Injury (TBI) Patients
Enrollment	600 participants
Start Date	2025-06-01
Primary Completion	2029-06 (estimated)
Study Completion	2029-09 (estimated)
Updated on ClinicalTrials.gov	2025-08-17