Clinical Trial

Understanding Non-invasive Vagus Nerve Stimulation Effects in PTSD

Study acronym: SPARK-VNS
Not Yet Recruiting Early Phase 1
View on ClinicalTrials.gov →
Summary
The goal of this study is to determine how non-invasive brain stimulation (delivered through the ear called vagus nerve stimulation) affects fear learning processes in people who have experienced psychological trauma. To answer these questions, we measure bodily responses (heart rate, sweat, startle) and questionnaires. The main questions it aims to answer are: Does non-invasive vagus nerve stimulation help reduce anxious arousal? Does non-invasive vagus nerve stimulation help dampen learned fear?
Protocol Amendment History 2 amendments
This ClinicalTrials.gov record has been amended 2 times since 2025-04-23; most recent amendment 2026-07-09.
Trial Details
NCT Number NCT06953388
Lead Sponsor Wayne State University
Conditions PTSD - Post Traumatic Stress Disorder
Enrollment 60 participants
Start Date 2027-04-01
Primary Completion 2031-03-01 (estimated)
Study Completion 2031-03-01 (estimated)
Updated on ClinicalTrials.gov 2026-07-13