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Understanding Non-invasive Vagus Nerve Stimulation Effects in PTSD

Study acronym: SPARK-VNS
StatusNot Yet Recruiting
PhaseEarly Phase 1
Started
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Record History

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  1. Phase: Phase 1 to Early Phase 1v3 Show 5 more changesShow less
    • Start date: Feb 1, 2026 to Apr 1, 2027
    • Primary endpoints: 5 to 1
    • Primary completion date: Jan 1, 2031 to Mar 1, 2031
    • Study completion date: Dec 2032 to Mar 1, 2031
    • Secondary endpoints expanded, about 15 words
  2. Re-verified, no change to tracked fieldsv2
  3. Study First Submitted
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
Wayne State University
48 trials monitored
See 1 trial at risk
PTSD
889 trials monitored
See 54 trials at risk
The goal of this study is to determine how non-invasive brain stimulation (delivered through the ear called vagus nerve stimulation) affects fear learning processes in people who have experienced psychological trauma. To answer these questions, we measure bodily responses (heart rate, sweat, startle) and questionnaires. The main questions it aims to answer are: Does non-invasive vagus nerve stimulation help reduce anxious arousal? Does non-invasive vagus nerve stimulation help dampen learned fear?
Trial Details
NCT Number NCT06953388
Lead Sponsor Wayne State University
Conditions
(from sponsor)		 PTSD - Post Traumatic Stress Disorder
Related terms Combat Disorders, Stress Disorders, Post-Traumatic
Enrollment 60 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov