Intraoperative Hypotension in Pancreatoduodenectomy: A Randomized Trial of General Versus Combined Anesthesia

This randomized clinical trial compares the hemodynamic effects of general anesthesia versus combined general anesthesia (thoracic epidural) in patients undergoing pancreatoduodenectomy. The primary aim is to assess the incidence of intraoperative hypotension and related adverse events. Secondary outcomes includes vasopressor requirements, transfusion needs, postoperative complications, intensive care unit admission, hospital length of stay, and mortality.

NCT Number	NCT06953193
Lead Sponsor	Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran
Conditions	Pancreatic Neoplasms, Hypotension, Pancreatoduodenectomy
Enrollment	206 participants
Start Date	2025-04-07
Primary Completion	2030-01-07 (estimated)
Study Completion	2030-04-30 (estimated)
Updated on ClinicalTrials.gov	2026-04-01