Clinical Trial

Effect of Ciprofol on Intraoperative Hypotension in Elderly Patients Receiving Renin-angiotensin System Inhibitors

Recruiting Phase 4
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Record status
This record was last updated December 30, 2025 (before its estimated February 10, 2026 completion). Its status may not reflect the trial's current state.
Summary
The prevention of intraoperative hypotension could reduce postoperative organ injury and mortality, particularly in elderly patients receiving long-term renin-angiotensin system inhibitors. Previous meta-analyses suggest that ciprofol, a novel intravenous anesthetic agent, may provide improved hemodynamic stability compared to propofol; however, its precise effects on perioperative hemodynamics remain unclear. The study will assess whether ciprofol improves perioperative hemodynamic stability in elderly patients receiving renin-angiotensin system inhibitors.
Protocol Amendment History 1 change
notable Sponsor changed: Second Affiliated Hospital, School of Medicine, Zhejiang University -> Second Affiliated Hospital, Zhejiang University, School of Medicine 2026-08-09
Trial Details
NCT Number NCT06952608
Lead Sponsor Second Affiliated Hospital, School of Medicine, Zhejiang University
Conditions Intraoperative Hypotension, Ciprofol, Renin-angiotensin System Inhibitors
Enrollment 140 participants
Start Date 2025-04-10
Primary Completion 2026-02-10 (estimated)
Study Completion 2026-04-10 (estimated)
Updated on ClinicalTrials.gov 2025-12-30